I Tried the Craziest Vitamin D Protocol
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Date: 2025-12-12
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Comments and reviews: 20
swingister
You are missing way too much information here. First always take vitamin D with K2. Vitamin k2 tells the calcium where to go in the body. You can buy vitamin D with K2 in it. This is very important. Otherwise high dose vitamin D can lead to calcium being deposited in soft tissues instead of in the bones and teeth. This is especially true of people taking calcium and or have a high calcium diet. Also take magnesium. Magnesium is essential for the absorption of vitamin D. The enzymes that are responsible for metabolizing vitamin D all seem to require magnesium. If your magnesium level is too low, your body cannot activate or process vitamin D. You would be better to take Vitamin D on a daily bases. That way you can pare it with magnesium and vitamin k2. You can od on vitamin D. There are some reports on this, but it's difficult. For most situations geting a level between 70 and 100 would be good. For example a life guard sitting in the sun all day comes out with a level in the 70s. This seems to be an optimal range between 70 and 100. Going higher is good for healing certain conditions like MS but for most of us its not helpful and can be dangerous if we do not control our calcium intake. You are funny as always, but this is not one of my favorite videos of yours. It goes up there with your hair restoration video.
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You are missing way too much information here. First always take vitamin D with K2. Vitamin k2 tells the calcium where to go in the body. You can buy vitamin D with K2 in it. This is very important. Otherwise high dose vitamin D can lead to calcium being deposited in soft tissues instead of in the bones and teeth. This is especially true of people taking calcium and or have a high calcium diet. Also take magnesium. Magnesium is essential for the absorption of vitamin D. The enzymes that are responsible for metabolizing vitamin D all seem to require magnesium. If your magnesium level is too low, your body cannot activate or process vitamin D. You would be better to take Vitamin D on a daily bases. That way you can pare it with magnesium and vitamin k2. You can od on vitamin D. There are some reports on this, but it's difficult. For most situations geting a level between 70 and 100 would be good. For example a life guard sitting in the sun all day comes out with a level in the 70s. This seems to be an optimal range between 70 and 100. Going higher is good for healing certain conditions like MS but for most of us its not helpful and can be dangerous if we do not control our calcium intake. You are funny as always, but this is not one of my favorite videos of yours. It goes up there with your hair restoration video.
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samalama918
Perhaps this is addressed further in the video, yet being a numbers guy there is on part that irks me a bit.
In the study where elderly women were given either a 300, 000 IU mega dose one time or 800 IU each day, it states that after 4 weeks the mega dose was the clear winner. Well, that makes total sense given it's a fat soluble vitamin and 300, 000 is 375X larger than 800. If you took 800 IU for an entire year you wouldn't even have taken 300, 000 IU. Even after 12 weeks you would have only consumed 67, 200 IU when taking 800 each day, so given you store vitamin D it should be clear that your levels would be higher with the mega dose.
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Perhaps this is addressed further in the video, yet being a numbers guy there is on part that irks me a bit.
In the study where elderly women were given either a 300, 000 IU mega dose one time or 800 IU each day, it states that after 4 weeks the mega dose was the clear winner. Well, that makes total sense given it's a fat soluble vitamin and 300, 000 is 375X larger than 800. If you took 800 IU for an entire year you wouldn't even have taken 300, 000 IU. Even after 12 weeks you would have only consumed 67, 200 IU when taking 800 each day, so given you store vitamin D it should be clear that your levels would be higher with the mega dose.
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wrusst
So daily dose equaling 22. 4k or at 22 weeks 67k vs 1 at 300k This doesn't suggest to me that's it's more effective if anything that's a very poor result and high loss of efficiency as these aren't even near comparable total d3 taken.
67k kinda caught up is an awful result at week imo.
Tolerable upper limit is 4k vs 800 given and even then your no where near the 300k group.
This just seems like searching for a result you want when a paper doesn't even attempt to address this massive shortfall 4k daily x 4 week vs 112k once would find out what more effective and the efficiency loss or gain of a single bolus dose
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So daily dose equaling 22. 4k or at 22 weeks 67k vs 1 at 300k This doesn't suggest to me that's it's more effective if anything that's a very poor result and high loss of efficiency as these aren't even near comparable total d3 taken.
67k kinda caught up is an awful result at week imo.
Tolerable upper limit is 4k vs 800 given and even then your no where near the 300k group.
This just seems like searching for a result you want when a paper doesn't even attempt to address this massive shortfall 4k daily x 4 week vs 112k once would find out what more effective and the efficiency loss or gain of a single bolus dose
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ryan_humiston
People, please get your Vitamin D levels tested before supplementing and when supplementing get it checked regularly. Don't just willy-nilly supplement things, very high Vitamin D levels have serious potential long term negative consequences. While Vitamin D does help get calcium into your bones, too much Vitamin D in your bloodstream will actually have the opposite effect and leech calcium from your bones. High blood calcium has all kinds of potential deleterious effects like kidney stones, arterial calcification, and in extreme cases heart arrythmias.
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People, please get your Vitamin D levels tested before supplementing and when supplementing get it checked regularly. Don't just willy-nilly supplement things, very high Vitamin D levels have serious potential long term negative consequences. While Vitamin D does help get calcium into your bones, too much Vitamin D in your bloodstream will actually have the opposite effect and leech calcium from your bones. High blood calcium has all kinds of potential deleterious effects like kidney stones, arterial calcification, and in extreme cases heart arrythmias.
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lenartd2
So, there were findings in Saudi Arabia where during their time of praying numerous people had collapsed of the heat and dehydration. They were rushed into hospitals, blood taken for analysis and then sent off again after they had recovered. Oddly, each of the blood test resulted in highly elevated vitamin D. Later it was confirmed that this vitamin got activated by the extrem change of temperature from 45C outside to an A/C chilled 19C in the hospital. Basically: got to suffer a little in both directions to get the benefit
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So, there were findings in Saudi Arabia where during their time of praying numerous people had collapsed of the heat and dehydration. They were rushed into hospitals, blood taken for analysis and then sent off again after they had recovered. Oddly, each of the blood test resulted in highly elevated vitamin D. Later it was confirmed that this vitamin got activated by the extrem change of temperature from 45C outside to an A/C chilled 19C in the hospital. Basically: got to suffer a little in both directions to get the benefit
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Mohammed-l8b8e
vitamin d need k2 100mcg with each 10000IU Also Vitamin D Need Magnesium And Zinc To Work i take 10000IU Per Day With 100mcg K2 I Try To Get higher Because There Are Lot Of Factors That Weaken The Absorption Like Insulin Resistance or Kidney Problem Liver Problem genetic problem and more and more that low doses like 800 are nothing because half hour in the sun depend on region will give you 10000iu also you need cholesterol to absorb vitamin d from te sun and magnesium and zinc to convert it to active form
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vitamin d need k2 100mcg with each 10000IU Also Vitamin D Need Magnesium And Zinc To Work i take 10000IU Per Day With 100mcg K2 I Try To Get higher Because There Are Lot Of Factors That Weaken The Absorption Like Insulin Resistance or Kidney Problem Liver Problem genetic problem and more and more that low doses like 800 are nothing because half hour in the sun depend on region will give you 10000iu also you need cholesterol to absorb vitamin d from te sun and magnesium and zinc to convert it to active form
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Angel-gi1bi
Hypothesis: A single massive dose (300, 000 IU) is a superior therapeutic strategy because it rapidly corrects deficiency and ensures long-term storage.
Counterexample: Mega-doses can induce a paradoxical functional deficiency by upregulating the enzyme CYP24A1, which degrades Vitamin D metabolites to prevent toxicity. This explains why the bolus group failed to improve muscle function despite high blood markers; the active hormone was likely catabolized before it could act on muscle receptors.
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Hypothesis: A single massive dose (300, 000 IU) is a superior therapeutic strategy because it rapidly corrects deficiency and ensures long-term storage.
Counterexample: Mega-doses can induce a paradoxical functional deficiency by upregulating the enzyme CYP24A1, which degrades Vitamin D metabolites to prevent toxicity. This explains why the bolus group failed to improve muscle function despite high blood markers; the active hormone was likely catabolized before it could act on muscle receptors.
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Angel-gi1bi
Hypothesis: Achieving the highest possible serum 25(OH)D levels is the primary determinant for clinical improvement in target tissues like skeletal muscle.
Counterexample: The study explicitly contradicts this: the single-dose group achieved significantly higher serum levels yet saw no improvement in muscle strength. Conversely, the daily group had lower serum peaks but significant functional strength gains, proving that steady bioavailability matters more than peak serum concentration.
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Hypothesis: Achieving the highest possible serum 25(OH)D levels is the primary determinant for clinical improvement in target tissues like skeletal muscle.
Counterexample: The study explicitly contradicts this: the single-dose group achieved significantly higher serum levels yet saw no improvement in muscle strength. Conversely, the daily group had lower serum peaks but significant functional strength gains, proving that steady bioavailability matters more than peak serum concentration.
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Angel-gi1bi
Hypothesis: Ryan’s Vitamin D level of 39 ng/ml is critically low and requires aggressive supplementation to reach an optimal range of 50 ng/ml.
Counterexample: The National Academy of Medicine (formerly IOM) defines >20 ng/ml as sufficient for bone health in 97. 5% of the population. The Endocrine Society (2024) has shifted its stance, advising against routine testing for healthy adults, acknowledging that levels above 20-30 ng/ml offer no additional protection against bone fractures.
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Hypothesis: Ryan’s Vitamin D level of 39 ng/ml is critically low and requires aggressive supplementation to reach an optimal range of 50 ng/ml.
Counterexample: The National Academy of Medicine (formerly IOM) defines >20 ng/ml as sufficient for bone health in 97. 5% of the population. The Endocrine Society (2024) has shifted its stance, advising against routine testing for healthy adults, acknowledging that levels above 20-30 ng/ml offer no additional protection against bone fractures.
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Angel-gi1bi
Hypothesis: High-dose supplementation is harmless because specific cases (like the nursing home example) showed no immediate adverse events.
Counterexample: Absence of immediate acute failure does not equal long-term safety; excess Vitamin D is stored in fat and liver, leading to potential chronic toxicity and vascular calcification. Whole food sources and sun exposure trigger natural feedback loops that stop production when levels are sufficient, a safety mechanism supplements lack.
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Hypothesis: High-dose supplementation is harmless because specific cases (like the nursing home example) showed no immediate adverse events.
Counterexample: Absence of immediate acute failure does not equal long-term safety; excess Vitamin D is stored in fat and liver, leading to potential chronic toxicity and vascular calcification. Whole food sources and sun exposure trigger natural feedback loops that stop production when levels are sufficient, a safety mechanism supplements lack.
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AbuBakir0
I have done 300, 000IU doses more than 20 times maybe, but without taking daily doses, when my levels would get low, like below 20, I would just take 300K IU of vitamin d3 and I would take it 3 times every 10 days but with vitamin K2 and magnesium glycinate too so there literally basically 0 side effects and I feel absolutely amazing whenever my levels get higher, I'd shoot for at least 50, ideally around 70-90 is very good then U can take 5000IU daily for maintenance
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I have done 300, 000IU doses more than 20 times maybe, but without taking daily doses, when my levels would get low, like below 20, I would just take 300K IU of vitamin d3 and I would take it 3 times every 10 days but with vitamin K2 and magnesium glycinate too so there literally basically 0 side effects and I feel absolutely amazing whenever my levels get higher, I'd shoot for at least 50, ideally around 70-90 is very good then U can take 5000IU daily for maintenance
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Angel-gi1bi
Hypothesis: Sun exposure is unreliable for Vitamin D synthesis due to genetic factors and location, making synthetic supplementation the only reliable option.
Counterexample: The body’s ability to self-regulate Vitamin D from the sun prevents toxicity, which is a significant risk with unchecked supplementation. Adequate levels can often be maintained through moderate sun exposure and eating UV-exposed mushrooms, avoiding the need for synthetic isolation.
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Hypothesis: Sun exposure is unreliable for Vitamin D synthesis due to genetic factors and location, making synthetic supplementation the only reliable option.
Counterexample: The body’s ability to self-regulate Vitamin D from the sun prevents toxicity, which is a significant risk with unchecked supplementation. Adequate levels can often be maintained through moderate sun exposure and eating UV-exposed mushrooms, avoiding the need for synthetic isolation.
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Angel-gi1bi
Hypothesis: Standard recommended doses (800 IU) are ineffective, and mega-dosing (300, 000 IU) is a superior, safe method for optimizing health.
Counterexample: Mega-dosing forces artificial spikes in hormones, bypassing the body's tight regulation and increasing the risk of hypercalcemia and kidney stones. A consistent WFPB lifestyle promotes steady, safe nutrient absorption rather than shock-dosing the endocrine system with isolated compounds.
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Hypothesis: Standard recommended doses (800 IU) are ineffective, and mega-dosing (300, 000 IU) is a superior, safe method for optimizing health.
Counterexample: Mega-dosing forces artificial spikes in hormones, bypassing the body's tight regulation and increasing the risk of hypercalcemia and kidney stones. A consistent WFPB lifestyle promotes steady, safe nutrient absorption rather than shock-dosing the endocrine system with isolated compounds.
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Angel-gi1bi
Hypothesis: Vitamin D2 (plant-derived) is inferior to Vitamin D3 (animal-derived) and should be avoided due to poor conversion rates.
Counterexample: Research indicates that Vitamin D2 is effective at raising and maintaining serum levels when consumed daily. Furthermore, obtaining nutrients from whole plant sources avoids the inflammatory markers associated with animal-derived D3 and provides necessary co-nutrients missing in isolated extracts.
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Hypothesis: Vitamin D2 (plant-derived) is inferior to Vitamin D3 (animal-derived) and should be avoided due to poor conversion rates.
Counterexample: Research indicates that Vitamin D2 is effective at raising and maintaining serum levels when consumed daily. Furthermore, obtaining nutrients from whole plant sources avoids the inflammatory markers associated with animal-derived D3 and provides necessary co-nutrients missing in isolated extracts.
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Angel-gi1bi
Hypothesis: Comparison between 300, 000 IU bolus and 800 IU daily provides a medically equivalent baseline for determining efficacy.
Counterexample: This is an asymmetrical comparison; 800 IU is a maintenance dose, while 300, 000 IU is a supraphysiological shock. A fairer scientific comparison would have been a daily therapeutic dose (e. g, 4, 0005, 000 IU) to see if the muscle strength gains were dose-dependent or frequency-dependent.
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Hypothesis: Comparison between 300, 000 IU bolus and 800 IU daily provides a medically equivalent baseline for determining efficacy.
Counterexample: This is an asymmetrical comparison; 800 IU is a maintenance dose, while 300, 000 IU is a supraphysiological shock. A fairer scientific comparison would have been a daily therapeutic dose (e. g, 4, 0005, 000 IU) to see if the muscle strength gains were dose-dependent or frequency-dependent.
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ryan_humiston
Ingesting such a large amount of vitamin D regularly is a bad idea. Having so much vitamin D in your blood for an extended period of time increases your bloods calcium solubility in plasma and can cause your bones to literally dissolve into your blood stream. There’s a chubbyemu video about a kid that ate vitamin gummies like regular gummies and wound up with all of his bones shattering at random.
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Ingesting such a large amount of vitamin D regularly is a bad idea. Having so much vitamin D in your blood for an extended period of time increases your bloods calcium solubility in plasma and can cause your bones to literally dissolve into your blood stream. There’s a chubbyemu video about a kid that ate vitamin gummies like regular gummies and wound up with all of his bones shattering at random.
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Pierre_da_Chello
If you’re in your 20s or 30s and think your energy’s fine, it’s not. Do yourself a favor and read book called TestoGenesis Protocol by Angelico. It’s the kind of stuff no doctor or influencer ever talks about. Pure truth about testosterone and how to keep it strong for life.
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If you’re in your 20s or 30s and think your energy’s fine, it’s not. Do yourself a favor and read book called TestoGenesis Protocol by Angelico. It’s the kind of stuff no doctor or influencer ever talks about. Pure truth about testosterone and how to keep it strong for life.
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alexzaharchuk6714
It blows my mind how under the radar book called TestoGenesis Protocol by Angelico still is. It’s honestly the most practical thing I’ve read on getting your testosterone and energy back, no fake hacks, no bro science, just straight facts. Unreal how few people know about it.
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It blows my mind how under the radar book called TestoGenesis Protocol by Angelico still is. It’s honestly the most practical thing I’ve read on getting your testosterone and energy back, no fake hacks, no bro science, just straight facts. Unreal how few people know about it.
reply
cacacaca9844
If you’re in your 20s or 30s and think your energy’s fine, it’s not. Do yourself a favor and read book called TestoGenesis Protocol by Angelico. It’s the kind of stuff no doctor or influencer ever talks about. Pure truth about testosterone and how to keep it strong for life.
reply
If you’re in your 20s or 30s and think your energy’s fine, it’s not. Do yourself a favor and read book called TestoGenesis Protocol by Angelico. It’s the kind of stuff no doctor or influencer ever talks about. Pure truth about testosterone and how to keep it strong for life.
reply
proggerize
Vitamin D is nothing more than a sunscreen that the body produces to protect the skin from sunburn. And cancer risk reduction (other than skin cancer) is just a proxy for outdoor activity. See Dr. Paul Mason - 'The 5 Minute Vitamin D Talk', it will open your eyes about vitamin D.
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Vitamin D is nothing more than a sunscreen that the body produces to protect the skin from sunburn. And cancer risk reduction (other than skin cancer) is just a proxy for outdoor activity. See Dr. Paul Mason - 'The 5 Minute Vitamin D Talk', it will open your eyes about vitamin D.
reply
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