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zakruti.com » Knowledge, science, education » WIRED
Biologist Explains One Concept in 5 Levels of Difficulty - CRISPR

Biologist Explains One Concept in 5 Levels of Difficulty - CRISPR

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Rating: 4.0; Vote: 1
CRISPR is a new area of biomedical science that enables gene editing and could be the key to eventually curing diseases like autism or cancer. WIRED has challenged biologist Neville Sanjana to explain this concept to 5 different people; a 7 year-old, a 14 year-old, a college student, a grad student and a CRISPR expert. Find out more about Neville's work at
Date: 2022-07-06

Comments and reviews: 10


it annoys me when people teach concepts using metaphors (like the instruction manual) and then don-t quite explain the way in which that metaphor applies to reality. that child is gonna think his body just -has instructions- and- that won-t have taught him much. ofc this is just an example and it-s really hard to explain complex concepts to people who-ve never even heard of them in the most friendly way posible so this is not on the guy explaining, but this led to so much confusion for me personally growing up. i-ve always had teachers explain things in this sort of ways and in the end, you realize you haven-t learned a thing because you-re not possibly capable of explaining that thing without recurring to that metaphor, like if it was a part of what the concept is. you just end up remembering an explanation instead of learning the meaning.
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Billions of years of evolutionary life, now being reduced to a product to make a profit. Progress is all well and good, but when the motivation is to bring products to market, I doubt this is going to end well. Call me crazy, but this 'war-like' economic system is not one you want to have when humans start figuring out how to edit gene expressions
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I'm autistic, and I sort of like it. There are obviously downsides that come with it, like for me I struggle with mathematics. But I'm good at English and languages in general, according to my school. I wouldn't trade it for anything. Even if I wasn't good at English or language I like the way I am and I don't want to be -Normal-
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idk if it-s common in the us but in germany we started learning about crispr in 7th grade and also had discussions abt it in other classes bc of the ethic aspect, I-m just wondering if sb could answer how teaching stuff like that works and if it-s like limited to one class for students in the us or not, rlly interested
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During the video, I made a connection between breeding and Casper; hear me out.
When you breed animals, you take 2 animals that have DNA genes that a breeder would want to combine.
With Casper, you're just getting rid of the gene in all.

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I attended high school in Italy and i learned about Crisper during biology class like it was at the same level of knowing the mitochondria is the power house of the cell.
I think its really nice how they teach biotechnology in high school here!

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Okay so Crispr is not about changing the aesthetics of a person which is what we think of first because we're no where close to even understanding how to do that. It's really about learning about DNA and the genome and RNA how it all works.
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level 1: we do crispr on humans
level 2: we do crispr on humans but not for cosmetics
level 3: we don-t do crispr on humans but maybe we do
level 4: we don-t do crispr on humans
level 5: we don-t let crispr escape out of the lab

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Changing eye color has been possible since at least 8 years. An Australian friend of mine that was ginger did it through biohacking 8 years ago so maybe it has been around since even longer than that. It changed his hair and eye color.
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You observed that the CRISPR knock-out of protein X either promotes or represses RNA polymerase II transcription, depending on the gene. Which experiments would you carry out to reveal the mechanism for this differential activity?
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